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Category: MRI

  • Hyperpolarization Research: Unveiling Real-Time Metabolism

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    Josh
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    Abstract: Hyperpolarization (HP) magnetic resonance imaging (MRI) and spectroscopy (MRS) have revolutionized the field of molecular imaging by dramatically enhancing the sensitivity of nuclear magnetic resonance (NMR) for low-gamma nuclei, particularly carbon-13 ($^{13}$C). This transient yet powerful signal boost allows for the real-time, non-invasive interrogation of metabolic pathways and physiological processes in vivo at unprecedented…

  • Beyond the Bond: Unveiling Molecular Architecture with the Nuclear Overhauser Effect

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    Josh
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    Table of Contents The Quantum Engine: Theory and Mechanisms of the NOE Nuclear Spin Dynamics and Energy Levels: The Quantum Foundation of Magnetic Resonance Having introduced the fascinating ‘dipolar dance’ that underpins the Nuclear Overhauser Effect (NOE), we now pivot from the macroscopic observation of through-space communication to the fundamental quantum mechanical principles governing nuclear…

  • Summary of MRI Advances

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    Josh
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    Magnetic Resonance Imaging (MRI) stands as a cornerstone in modern diagnostic medicine, offering unparalleled non-invasive visualization of the body’s internal structures and functions, particularly soft tissues. Its ability to provide detailed anatomical images without relying on ionizing radiation distinguishes it from other modalities like X-rays and Computed Tomography (CT) (National Institute of Biomedical Imaging and…

  • Hyperpolarized Carbon-13 MRI: Principles, Techniques, and Applications

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    Josh
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    Table of Contents Chapter 1: Introduction to Hyperpolarization and Carbon-13 MRI: A Paradigm Shift in Molecular Imaging 1.1 Historical Context and Limitations of Conventional MRI and PET: Paving the Way for Molecular Imaging Conventional Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) have revolutionized medical diagnostics, providing invaluable insights into human anatomy and physiology.…

  • Carbon-13 MRI

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    Josh
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    Chapter 1: A Silent Revolution: Introducing Carbon-13 MRI and its Potential 1.1 The Metabolic Landscape: A Rationale for C-13 MRI – Briefly discuss the importance of metabolism in health and disease, limitations of current metabolic imaging techniques (e.g., PET with FDG), and the specific advantages of targeting carbon metabolism for improved diagnostics and understanding of…

  • Resonance: A Mathematical Foundation of NMR Spectroscopy and Chemical Structure

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    Josh
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    Chapter 1: Introduction to Nuclear Magnetic Resonance: A Chemical Perspective 1.1 The Chemical Origins of NMR: Connecting Molecular Structure to Spectroscopic Parameters Nuclear Magnetic Resonance (NMR) spectroscopy has become an indispensable tool for chemists across diverse fields, from elucidating the structure of complex natural products to probing the dynamics of biological macromolecules. Its power lies…

  • MRI Pulse Sequences and Mathematics

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    Josh
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    Chapter 1: Laying the Foundation: A Review of Linear Algebra and Signal Processing for MRI 1.1 Vector Spaces, Linear Transformations, and Basis Functions in MRI: Exploring k-space as a Vector Space and the Fourier Transform as a Linear Transformation In the realm of Magnetic Resonance Imaging (MRI), a profound understanding of linear algebra is not…

  • Magnetic Resonance Imaging: A Dive into its Physics

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    Josh
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    Chapter 1: The Quantum Underpinnings: A Journey into Nuclear Spin and Magnetic Moments 1. The Intrinsic Angular Momentum: Demystifying Nuclear Spin and its Quantization At the heart of nuclear magnetic resonance (NMR) lies a fundamental property of atomic nuclei known as nuclear spin. Unlike the classical notion of a spinning top, nuclear spin is an…

  • MRI: Cryogen free tech

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    Josh
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    New Cryogen-Free Technology for Achieving Superconductivity Cryogen-free technology for superconductivity refers to systems that achieve and maintain the low temperatures required for superconducting states without relying on traditional cryogenic liquids like liquid helium (boiling point ~4.2 K) or liquid nitrogen (boiling point ~77 K). Instead, these systems use closed-cycle cryocoolers, such as pulse tube cryocoolers…

  • MRI: Quantum coherence

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    Josh
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    Multiple quantum coherence (MQC) is a central concept in nuclear magnetic resonance (NMR) spectroscopy, describing the correlated evolution of multiple nuclear spins in a quantum mechanical system. It plays a critical role in advanced NMR experiments, enabling the study of molecular structure, dynamics, and interactions with high resolution and sensitivity. Below, I provide a comprehensive…